New Antibiotics, motherfuckers!
Always an exciting day. The September 19, 2008 issue of Science reports the effectiveness of a compound directed at the guanosine triphosphatase FtsZ (which forms the septum at which (most) bacterial cells divide and another compound which acts bacteriostatically by inhibiting a histidine kinase that works in quorum sensing. And yes, the first one kills MRSA and MDRSA dead as a fucking hammer. Eukaryotes do use a similar kind of septating ring to complete cell division, but form it from a protein called tubulin; while tubulin and FtsZ are commonly derived, the new compound described does not have an effect upon tubulin ring formation in vitro, which means that we've got selective toxicity and a brand new scope for targeting bacterial infections.
"The whole conception of God is a conception derived from ancient Oriental despotisms. It is a conception quite unworthy of free men."