Inversion of Values
Nietzsche's criticisms of Judaism and Christianity referred to the inversion of values; taking the obviously desirable qualities of life, strength, happiness, and power, and commanding people to shun them. In the case that religious leaders are lying about an afterlife, this means that people are forced to condemn the only things they have to strive for and enjoy in this life, for literally nothing. This being something of a clever ruse for the grubbing lower classes to rot the bourgeois from the inside by convincing them what they have is bad for them, and that they should give it up (for the religious leaders to later rationalize taking for themselves, or course). Imagine clasping your empty hands in front of a dog until it drops its bone and runs over to you, finally convinced you have something better.
The idea is so pervasive and so perverse, and you find it in so many tragic thoughts and behaviors motivated by this religious interpretation. Even the rejection of evolutionary theory can find justification in the inversion of values. Evolution implies that things go from simple to complex; from poorly adapted to much better adapted. This is a reversal of the ideas at the heart of the Abrahamic religions. The first thing is a perfect god, and everything that follows gets progressively worse. God creates a perfect world, but it gets corrupted by Original Sin. The most important part of you, your soul, is something you can't even become aware of or prove; yet the senses are limited and corrupt. As though we're limited by, rather than to, sensory data; our only real window into awareness.
It's just a tragic waste of brain power, trying to fit the world into this inverted view.